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Conversations at HUPO 2026 revolved around questions that reach beyond the proteomics community: who will develop disease, why treatment fails, and whether a computational model can help us decide which experiment to run next. The post World HUPO 2026: Asia-Pacific Ambition and…
Scientists have discovered that switching off a protein called Mitch makes human cells burn more fat and prevents new fat cells from developing. The breakthrough builds on experiments in mice that showed remarkable resistance to obesity and improved muscular endurance, raising hopes…
Anthropic’s Form S-1 Registration Statement did not reveal what research areas it is pursuing through the molecular biology lab it disclosed last month, and what if any new therapies it is seeking to discover and develop. But the IPO filing said that…
A simple, steroid-free procedure could offer lasting relief for people struggling with carpal tunnel syndrome, potentially helping them avoid surgery. In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection, which uses fluid to free a compressed nerve in the…
In this GEN webinar, Bernd Bodenmiller, PhD (University of Zürich), illustrates this integrated approach through two recent examples. The post Spatial Proteomics for Precision Oncology appeared first on GEN - Genetic Engineering and Biotechnology News.
Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear…
Africa still imports 99% of its routine vaccines and 70–90% of its biopharmaceuticals. The Africa CDC warns this vulnerability could cost the continent up to $1.1 trillion in skills and jobs through 2050. The post South African Labs Strive for Africa’s Biopharma…
Scientists have uncovered a hidden layer of organization in the brain by creating the first detailed 3D map of its lipids, the fatty molecules essential for brain structure and communication. By analyzing millions of measurements from mouse brains, researchers identified 539 distinct…
The biggest challenge facing the biopharma industry isn’t scientific innovation. It’s manufacturing execution. Closing this gap is one of the greatest opportunities biopharma has today to enhance resilience and unlock the full value of its science. The post Overcoming Bottlenecks: Biopharma’s Big…
Scientists discovered a hidden “immune organ” inside the skull that acts as a rapid first responder against brain cancer in mice. Strengthening this local immune defense improved tumor rejection and survival, raising the possibility of new treatments that target the skull directly.
Researchers studying mice and human data identified a six gene signature, and developed a scorings system, that could help forecast acute myeloid leukemia patient survival, and potentially point to new therapeutic targets. The post Predicting Leukemia Survival May Be Aided by Six…
A popular vanilla flavoring in e-cigarettes may interfere with some of the earliest steps of human development. In lab experiments, vanillin caused embryonic stem cells to lose their ability to develop normally and pushed them toward forming only certain types of tissue.
Geoff Meyerson addressed the growth of U.S.-Chinese licensing/collaboration deals, the recent growth of IPOs, and the still-chilly climate for startups seeking financing in a recent interview with GEN. The post StockWatch: Investment Banker Talks U.S.-Chinese Deals, IPOs, and a Tough Climate for…
Silver nanoparticles can precisely slice DNA and create longer “sticky ends,” helping genetic fragments join up to five times more efficiently than conventional methods. The breakthrough could eventually simplify the construction of large DNA sequences for gene therapies, cancer vaccines, engineered drugs,…
Researchers developed an implantable, wirelessly powered electronic device, ECHO, that uses electrocatalysis to remove excess glucose from the bloodstream on demand, and could offer a drug-free approach to managing obesity and type 2 diabetes (T2D). The post Wirelessly Powered Electronic Implant, ECHO,…
A protein once thought to mainly protect chromosome ends may also be essential for keeping muscle stem cells ready to repair injuries. Researchers found that TRF2 helps these cells maintain their identity and coordinate the cycle of rest, repair, and renewal.
Researchers analyzed multiomic and clinical data from 2000 colorectal cancer samples and used an AI tool, iPhenMap, to help identify cancer cell vulnerabilities and drug combinations that could be used to treat MSS CRC. The post Multiomic Study of MSS CRC Identifies…
Scientists have created a silicon chip that can write dozens of DNA sequences simultaneously using electricity and water-based enzymes, offering a cleaner alternative to conventional DNA manufacturing. The breakthrough could eventually support portable DNA-writing devices and even massive DNA data storage, although…
Using cryo-EM and an AI-designed scaffold, researchers mapped how Andes hantavirus engages a receptor on human cells. The findings explain how antibodies block attachment and may highlight a potential target for antiviral development. The post Cryo-EM and AI-Designed Scaffold Reveal How Andes…
Osteopenia is a common but often overlooked condition that causes bones to become less dense and more fragile. Because it develops silently, many people only discover they have it after a fracture or bone scan. Aging, menopause, poor diet, and inactivity can…
A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing…
Using cannabis edibles and alcohol together may make drivers far more impaired than either substance alone, according to new research from Johns Hopkins. Even more concerning, common field sobriety tests often failed to detect the cannabis-related impairment.
Scientists at Cornell University may be closing in on the long-sought “holy grail” of male contraception: a safe, reversible, nonhormonal method that completely halts sperm production. In a breakthrough mouse study, researchers used a compound called JQ1 to temporarily shut down meiosis—the…
A newly identified gene mutation may help explain why schizophrenia patients struggle to update their understanding of reality. The mutation disrupts a brain circuit involved in flexible decision-making, causing mice to stick with outdated choices even when conditions change. Researchers pinpointed the…
Scientists at Michigan State University have uncovered the molecular “switch” that powers sperm for their final, high-speed dash toward an egg. By tracking how sperm use glucose as fuel, the team discovered how dormant cells suddenly flip into overdrive, burning energy in…
Researchers have discovered a biological switch that explains why movement keeps bones strong. The protein senses physical activity and pushes bone marrow stem cells to build bone instead of storing fat, slowing age-related bone loss. By targeting this “exercise sensor,” scientists believe…
Researchers have recreated a miniature human bone marrow system that mirrors the real structure found inside our bones. The model includes the full mix of cells and signals needed for blood production and even maintains this process for weeks. It could transform…
Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon-responsive T cells create a self-sustaining inflammatory loop that weakens blood production. Surprisingly, the mutant cells themselves…
Groundbreaking research shows that as men age, harmful genetic mutations in sperm become more common—not just from random chance, but because some are naturally favored. Advanced sequencing revealed dozens of genes under selective pressure, many linked to serious disorders. The work reveals…
Korean researchers found that low-dose radiation therapy eased knee pain and improved movement in people with mild to moderate osteoarthritis. The treatment, far weaker than cancer radiation, showed real benefits beyond placebo. With no side effects and strong trial results, the approach…
A new study shows glioblastoma isn’t confined to the brain—it erodes the skull and hijacks the immune system within skull marrow. The cancer opens channels that let inflammatory cells enter the brain, fueling its deadly progression. Even drugs meant to protect bones…
For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with fat, leaving them too weak to…
Mayo Clinic scientists uncovered how excessive drinking triggers fatty liver disease by disrupting the enzyme VCP, which normally prevents harmful protein buildup on fat droplets in the liver. Alcohol blocks this protective process, allowing fat to accumulate and damage liver cells.
Switching clocks twice a year disrupts circadian rhythms in ways that harm health. Stanford scientists found permanent standard time would reduce obesity and stroke rates nationwide, making it the strongest option over permanent daylight saving time or seasonal shifts.
Northwestern scientists have developed a new nanostructure that supercharges CRISPR’s ability to safely and efficiently enter cells, potentially unlocking its full power to treat genetic diseases. By wrapping CRISPR’s tools in spherical DNA-coated nanoparticles, researchers tripled gene-editing success rates, improved precision, and…
Researchers at the Salk Institute have used CRISPR to uncover hidden microproteins that control fat cell growth and lipid storage, identifying one confirmed target, Adipocyte-smORF-1183. This breakthrough could lead to more effective obesity treatments, surpassing the limitations of current drugs like GLP-1.
Scientists have discovered that flossing between your teeth could one day help vaccinate you. By targeting a uniquely permeable gum tissue called the junctional epithelium, this new method stimulates immunity right where many infections enter: the mouth, nose, and lungs. Using dental…
Radiation therapy, once thought of mainly as a local cancer treatment, is now showing power to awaken the immune system in surprising ways. Researchers discovered that combining radiation with immunotherapy can transform stubborn, unresponsive lung tumors into targets for immune attack—especially those…
In a groundbreaking UK first, eight healthy babies have been born using an IVF technique that includes DNA from three people—two parents and a female donor. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases…
USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative…
Research teams have created a versatile set of gene delivery systems that can reach different neural cell types in the human brain and spinal cord with exceptional accuracy. These delivery systems are a significant step toward future precise gene therapy to the…
Scientists report that they have learned how certain combinations of rearranged genes can promote the progression of a rare type of kidney cancer.
Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, a Stanford Medicine team found. They also identified compounds that could treat it.
A genetic mutation that can protect people against HIV appears to have originated in a single person living near the Black Sea up to 9,000 years ago. Researchers traced its history using DNA from modern populations and more than 900 ancient skeletons.…
Many mitochondrial diseases have been difficult to study and treat due to the inherent challenges in accessing mitochondrial DNA (mtDNA). Now, researchers have optimized mitochondrial-targeted compounds that can selectively modify the ratio of normal versus mutant mtDNA in patient-derived stem cells. This…
Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue this precise control should be applied to optimize new nanomedicines.
A new bone marrow imaging technique could change treatment for cancer, autoimmune disease and musculoskeletal disorders.
New research suggests that decreased activity of ELOVL2 -- a key enzyme in lipid metabolism -- accelerates white blood cell aging and alters genes associated with the onset of blood cancers.
A new study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive blood cancer for which the median survival time following diagnosis remains just 8.5 months.
Scientists have developed a new type of handheld multi-purpose radiation detector that comprehensively detects all types of ionizing radiation. The device can be used by industrial and medical radiation users, regulatory authorities, the nuclear energy industry, first responders and military users. The…
An international team of researchers has discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective treatment. The team reports that when the cardioprotective mechanism fails, it promotes the…
Chronic myeloid leukemia may seem to appear suddenly, but new research shows it begins years before diagnosis with an explosive surge of growth. Scientists tracked how a single genetic accident—the fusion of two genes into the notorious BCR::ABL1 "Philadelphia chromosome"—can spark runaway…
A research team has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes --…
Scientists have shown that a sequence of just three amino acids may reduce the severity of psoriasis, when applied topically in an emollient cream.
The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress TE activity and keep themselves healthy.
Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer.
The success of in vitro fertilization depends on many factors, one of which is sperm viability. A recent study documents a new way to select viable sperm and prolong their viability in the laboratory, reducing one source of variability during the process.
A research team has developed a new system to estimate a person's biological age -- a measure of how well their body has aged, rather than just counting the years since birth. Using just five drops of blood, this new method analyzes…
A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study. The discovery could lead to more effective bone marrow transplants and gene therapies.
Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes. The findings have the…
Researchers found that TEX38 and ZDHHC19 co-localize on the plasma membrane of spermatids and mediate S-palmitoylation of ARRDC5, a crucial protein for spermatogenesis. Disrupting either TEX38 or ZDHHC19 inhibited cytoplasm removal from the sperm head, resulting in deformed sperm and infertility in…
A research team has uncovered how a naturally occurring biological mechanism found in mammals is able to prevent sperm cells from interacting with an egg, preventing fertilization. The discovery, identified in rodent models, offers a new path for scientific research to help…
Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing. For many years, scientists assumed that blood production took place…
Drawing inspiration from the tardigrade, researchers developed a new strategy that may protect cancer patients from the side effects of radiation therapy.
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, researchers have identified a vulnerability that opens the door to new treatments.
Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings demonstrate the potential of this technology…
DNA hydrogels are biocompatible drug delivery systems for targeted therapeutic interventions. Conventional DNA hydrogels, formed with many DNA nanostructure units, lead to increased preparation costs and design complexities.
Scientists have developed a new systematic review to summarize for neurologists and other clinicians the evidence for epidural steroid injections and whether they reduce pain and disability for people with certain kinds of chronic back pain.
A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and…
Psoriasis is a chronic skin disease that manifests itself mainly with skin symptoms (dryness, itching, scaly skin, abnormal patches and plaques). It affects about 2% of the population and is mediated by an altered immune system response that triggers the proliferation of…
Researchers have developed a platform that emulates human bone marrow's native environment. This breakthrough addresses a critical need in medical science, as animal studies often fail to fully replicate the complexities of human marrow.
A team of researchers has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.
A new class of lipids improve the rates at which lipid nanoparticles (LNPs) successfully deliver RNA therapeutics and gene editing tools, promising to increase their effectiveness of such treatments.
Drugs like Ozempic, Wegovy, and Mounjaro are changing how millions lose weight, but they come with a hidden drawback: they can strip away muscle along with fat, sometimes making up nearly half of the weight lost. Scientists at the Salk Institute may…
The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the development of innovative therapeutic strategies to counter osteoporosis. Their research findings reveal the…
Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.
Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live cells with unprecedented detail. By combining computer simulations with live-cell imaging, researchers have uncovered how different probe designs influence cholesterol probe behavior. These probes could reveal how…
Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.
A new study has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.
Full view of how bones and joints form in the first trimester uncovers cells and pathways that could help diagnose and treat skeletal conditions in the future.
A new method to increase fusion-fuel efficiency would involve aligning the quantum spin of deuterium and tritium and changing the mix of the two fuels. The approach could boost tritium-burn efficiency by up to 10 times, reducing tritium needs and lowering fusion…
Exercise can have benefits at the level of neurons, through chemical and mechanical effects, researchers find. The discovery could inform exercise-related therapies for repairing damaged and deteriorating nerves.
With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also…
Scientists who arranged for 48 human bioengineered heart tissue samples to spend 30 days at the International Space Station report evidence that the low gravity conditions in space weakened the tissues and disrupted their normal rhythmic beats when compared to earth-bound samples…
Glioblastomas are highly aggressive, usually incurable brain tumors. If all therapeutic options are exhausted, patients have an average life expectancy of less than two years. Now researchers have made a surprising discovery: in the vicinity of glioblastomas, they found islands of highly…
In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise.
The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study.
What happens when measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.
Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The research revealed the biological mechanisms underlying the disease and showed…
Osteoporosis or the weakening of bones makes the aging population vulnerable to fractures and a decreased quality of life. The parathyroid hormone (PTH)-derived peptide -- teriparatide has demonstrated strong bone promoting effects. However, it is also to known to exert bone-resorbing effects.…
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